MucilAir™ Pool bronchial

MucilAir™-Pool bronchial is an in vitro tissue model reconstituted with a mix of bronchial cells from 5 different healthy human donors. This mix of cells is used to reconstitute an upper airway epithelium cultured at the air liquid interface (ALI). It is a powerful and predictive model for in vitro research and tests.
Being an upper airways model, MucilAir™-Pool bronchial tissue is mainly composed of the following cell types:

• Basal cells (progenitor cells)
• Goblet cells (mucus producing cells)
• Ciliated cells (with active cilia)

This model is used solely for test services (CRO activity) at Epithelix

Using a pool of donors have remarkable advantages:

• The individual donor response is averaged in one single epithelium.
• Experiments involving different donors are therefore less necessary
• Large batches of primary cells allows long term availabilities of the stocks (compared to stocks of monodonor)
• MucilAir™-Pool nasal is produced routinely at Epithelix, allowing fast delivery after ordering!

Since 2023 we produce MucilAir™-Pool bronchial with high standards of quality and reproducibility. The tissue production is GIVIMP certified since 2023.

A large panel of bronchial healthy donors are individually tested for their proliferation and differentiation capacities. A narrowed selection of 5 different donor candidates having similar characteristics is selected to constitute the pool. Functional QC finally validates the batch of donors.

To ensure high predictability, MucilAir™-Pool bronchial is solely reconstituted using low passage human primary cells. The primary cells are isolated from human biological samples, under ethical approval and donor consent. Each batch of tissue is delivered with a certificate of analysis (COA) with donor information and quality control (QC) results.

Our models mimic the same characteristics of in vivo tissues than MucilAir™.

MucilAir™-Pool bronchial can be used in any assays using MucilAir. Check out our panel of test services !