Publications
An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo
Cell Reports (Nov. 2024)
Zhou, Nian E.; Tang, Su; Bian, Xuelin; Parai, Maloy K.; Krieger, Inna V.; Flores, Armando; Jaiswal, Pradeep K.; Bam, Radha; Wood, Jeremy L.; Shi, Zhe; Stevens, Laura J.; Scobey, Trevor; Diefenbacher, Meghan V.; Moreira, Fernando R.; Baric, Thomas J.; Acharya, Arjun; Shin, Joonyoung; Rathi, Manish M.; Wolff, Karen C.; Riva, Laura; Bakowski, Malina A.; McNamara, Case W.; Catanzaro, Nicholas J.; Graham, Rachel L.; Schultz, David C.; Cherry, Sara; Kawaoka, Yoshihiro; Halfmann, Peter J.; Baric, Ralph S.; Denison, Mark R.; Sheahan, Timothy P.; Sacchettini, James C.
Quantitative modeling of <i>in vitro</i> data using an adverse outcome pathway for the risk assessment of decreased lung function in humans
Toxicology Letters (Mar. 2024)
Sewer, Alain; Talikka, Marja; Calvino-Martin, Florian; Luettich, Karsta; Iskandar, Anita
A 2022 avian H5N1 influenza A virus from clade 2.3.4.4b attaches to and replicates better in human respiratory epithelium than a 2005 H5N1 virus from clade 2.3.2.1
nan (Nov. 2024)
Bauer, Lisa; Leijten, Lonneke; Iervolino, Matteo; Chopra, Varun; Dijk, Laura van; Power, Mark; Spronken, Monique; Rijnink, Willemijn; Funk, Mathis; Vries, Rory D. de; Richard, Mathilde; Kuiken, Thijs; Riel, Debby van
Universal paramyxovirus vaccine design by stabilizing regions involved in structural transformation of the fusion protein
Nature Communications (May. 2024)
Langedijk, Johannes P. M.; Cox, Freek; Johnson, Nicole V.; van Overveld, Daan; Le, Lam; van den Hoogen, Ward; Voorzaat, Richard; Zahn, Roland; van der Fits, Leslie; Juraszek, Jarek; McLellan, Jason S.; Bakkers, Mark J. G.
Efficacious human metapneumovirus vaccine based on AI-guided engineering of a closed prefusion trimer
Nature Communications (Jul. 2024)
Bakkers, Mark J. G.; Ritschel, Tina; Tiemessen, Machteld; Dijkman, Jacobus; Zuffianò, Angelo A.; Yu, Xiaodi; van Overveld, Daan; Le, Lam; Voorzaat, Richard; van Haaren, Marlies M.; de Man, Martijn; Tamara, Sem; van der Fits, Leslie; Zahn, Roland; Juraszek, Jarek; Langedijk, Johannes P. M.
Tissue-based in vitro and ex vivo models for nasal permeability studies
Concepts and Models for Drug Permeability Studies (Jan. 2024)
nan
Alternative strategies to improve intranasal and nose-to-brain drug delivery
nan (Jun. 2024)
Corazza, Elisa <1995>
Local and systemic effects of microplastic particles through cell damage, release of chemicals and drugs, dysbiosis, and interference with the absorption of nutrients
Journal of Toxicology and Environmental Health, Part B (Nov. 2024)
Fröhlich, Eleonore
Design and Preclinical Evaluation of a Nanoparticle Vaccine against Respiratory Syncytial Virus Based on the Attachment Protein G
Vaccines (Mar. 2024)
Voorzaat, Richard; Cox, Freek; van Overveld, Daan; Le, Lam; Tettero, Lisanne; Vaneman, Joost; Bakkers, Mark J. G.; Langedijk, Johannes P. M.
Polyoxometalate exerts broad-spectrum activity against human respiratory viruses hampering viral entry
Antiviral Research (Jun. 2024)
Arduino, Irene; Francese, Rachele; Civra, Andrea; Feyles, Elisa; Argenziano, Monica; Volante, Marco; Cavalli, Roberta; Mougharbel, Ali M.; Kortz, Ulrich; Donalisio, Manuela; Lembo, David