Publications
The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern
Nature Communications (Feb. 2022)
Abdelnabi, Rana; Foo, Caroline S.; Jochmans, Dirk; Vangeel, Laura; De Jonghe, Steven; Augustijns, Patrick; Mols, Raf; Weynand, Birgit; Wattanakul, Thanaporn; Hoglund, Richard M.; Tarning, Joel; Mowbray, Charles E.; Sjö, Peter; Escudié, Fanny; Scandale, Ivan; Chatelain, Eric; Neyts, Johan
Pre-clinical evaluation of antiviral activity of nitazoxanide against SARS-CoV-2
eBioMedicine (Aug. 2022)
Driouich, Jean-Sélim; Cochin, Maxime; Touret, Franck; Petit, Paul-Rémi; Gilles, Magali; Moureau, Grégory; Barthélémy, Karine; Laprie, Caroline; Wattanakul, Thanaporn; Chotsiri, Palang; Hoglund, Richard M.; Tarning, Joel; Fraisse, Laurent; Sjö, Peter; Mowbray, Charles E.; Escudié, Fanny; Scandale, Ivan; Chatelain, Eric; Lamballerie, Xavier de; Solas, Caroline; Nougairède, Antoine
SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression
PLOS Biology (Nov. 2022)
Niemeyer, Daniela; Stenzel, Saskia; Veith, Talitha; Schroeder, Simon; Friedmann, Kirstin; Weege, Friderike; Trimpert, Jakob; Heinze, Julian; Richter, Anja; Jansen, Jenny; Emanuel, Jackson; Kazmierski, Julia; Pott, Fabian; Jeworowski, Lara M.; Olmer, Ruth; Jaboreck, Mark-Christian; Tenner, Beate; Papies, Jan; Walper, Felix; Schmidt, Marie L.; Heinemann, Nicolas; Möncke-Buchner, Elisabeth; Baumgardt, Morris; Hoffmann, Karen; Widera, Marek; Thao, Tran Thi Nhu; Balázs, Anita; Schulze, Jessica; Mache, Christin; Jones, Terry C.; Morkel, Markus; Ciesek, Sandra; Hanitsch, Leif G.; Mall, Marcus A.; Hocke, Andreas C.; Thiel, Volker; Osterrieder, Klaus; Wolff, Thorsten; Martin, Ulrich; Corman, Victor M.; Müller, Marcel A.; Goffinet, Christine; Drosten, Christian
Optimizing the Live Attenuated Influenza A Vaccine Backbone for High-Risk Patient Groups
Journal of Virology (Oct. 2022)
Bonifacio, João P. P. L.; Williams, Nathalia; Garnier, Laure; Hugues, Stephanie; Schmolke, Mirco; Mazel-Sanchez, Beryl
Rapalogs downmodulate intrinsic immunity and promote cell entry of SARS-CoV-2
The Journal of Clinical Investigation (Dec. 2022)
Shi, Guoli; Chiramel, Abhilash I.; Li, Tiansheng; Lai, Kin Kui; Kenney, Adam D.; Zani, Ashley; Eddy, Adrian C.; Majdoul, Saliha; Zhang, Lizhi; Dempsey, Tirhas; Beare, Paul A.; Kar, Swagata; Yewdell, Jonathan W.; Best, Sonja M.; Yount, Jacob S.; Compton, Alex A.
Haemagglutinin substitutions N125D, D127E, D222G and R223Q improve replicative fitness and vaccine effectiveness of an A/H1N1pdm09 live attenuated influenza vaccine virus by enhancing α-2,6 receptor binding
PLOS Pathogens (Jan. 2022)
Dempsey, Rachael; Tamburrino, Giulia; Schewe, Katarzyna E.; Crowe, Jonathan; Nuccitelli, Annalisa; Dibben, Oliver
In Vitro Systems for Toxicity Evaluation of Microbial Volatile Organic Compounds on Humans: Current Status and Trends
Journal of Fungi (Jan. 2022)
Cerimi, Kustrim; Jäckel, Udo; Meyer, Vera; Daher, Ugarit; Reinert, Jessica; Klar, Stefanie
The altered entry pathway and antigenic distance of the SARS-CoV-2 Omicron variant map to separate domains of spike protein
nan (Jan. 2022)
Peacock, Thomas P.; Brown, Jonathan C.; Zhou, Jie; Thakur, Nazia; Sukhova, Ksenia; Newman, Joseph; Kugathasan, Ruthiran; Yan, Ada W.C.; Furnon, Wilhelm; De Lorenzo, Giuditta; Cowton, Vanessa M.; Reuss, Dorothee; Moshe, Maya; Quantrill, Jessica L.; Platt, Olivia K.; Kaforou, Myrsini; Patel, Arvind H.; Palmarini, Massimo; Bailey, Dalan; Barclay, Wendy S.
In vitro airway models from mice, rhesus macaques, and humans maintain species differences in xenobiotic metabolism and cellular responses to naphthalene
American Journal of Physiology-Lung Cellular and Molecular Physiology (Sep. 2022)
Kelty, Jacklyn; Kovalchuk, Nataliia; Uwimana, Eric; Yin, Lei; Ding, Xinxin; Van Winkle, Laura
Advancing New Approach Methodologies (NAMs) for Tobacco Harm Reduction: Synopsis from the 2021 CORESTA SSPT—NAMs Symposium
Toxics (Dec. 2022)
Lee, Kyeonghee Monica; Corley, Richard; Jarabek, Annie M.; Kleinstreuer, Nicole; Paini, Alicia; Stucki, Andreas O.; Bell, Shannon