Publications
Ensitrelvir treatment–emergent amino acid substitutions in SARS-CoV-2 3CLpro detected in the SCORPIO-SR phase 3 trial
Antiviral Research (Apr. 2025)
Uehara, Takeki; Yotsuyanagi, Hiroshi; Ohmagari, Norio; Doi, Yohei; Yamato, Masaya; Imamura, Takumi; Sakaguchi, Hiroki; Fukushi, Akimasa; Takeda, Yosuke; Baba, Keiko; Nobori, Haruaki; Miyamoto, Tadashi; Arita, Shuhei; Dodo, Reiko; Shimba, Alice; Fukao, Keita; Shishido, Takao; Tsuge, Yuko; Mukae, Hiroshi
An orally available Mpro/TMPRSS2 bispecific inhibitor with potent anti-coronavirus efficacy in vivo
Nature Communications (Jul. 2025)
Shuai, Huiping; Qiao, Jingxin; Yoon, Chaemin; Zhang, Guo; Hou, Yuxin; Xia, Xiaoyan; Wang, Lei; Deng, Xinyue; Wang, Yifei; Li, Qingquan; Du, Lianzhao; Liu, Yuanchen; Zhou, Minmin; Wong, Hoi Ting; Hu, Jiaheng; Liu, Huan; Hu, Bingjie; Wang, Dong; Su, Jingyi; Pan, Yuying; Ye, Yongtao; Chen, Yan; Fang, Zhen; Xia, Ziyi; Chai, Yue; Shi, Jialu; Wang, Yang; Zhu, Tianrenzheng; Zhang, Honglei; Yuan, Shuofeng; Zhou, Jie; Chan, Jasper Fuk-Woo; Yuen, Kwok-Yung; Xu, Chunfu; Lei, Jian; Yang, Shengyong; Chu, Hin
Optimal preclinical models for human dose projection of SARS-CoV-2 small molecule direct-acting antivirals
nan (Sep. 2025)
Toselli, Francesca; Jacobs, Sofie; Scheers, Els; Jacobs, Tom; Doijen, Jordi; Hereijgers, Joyce; Keustermans, Ken; Aerts, Liese; van Heerden, Marjolein; Van Loock, Marnix; Mason, Stephen W.; Monshouwer, Mario; Van Damme, Ellen; Herschke, Florence
A pan-respiratory virus attachment inhibitor with high potency in human airway models and in vivo
Science Advances (Aug. 2025)
Mathez, Gregory; Silva, Paulo Jacob; Carlen, Vincent; Deloizy, Charlotte; Prompt, Clémentine; Hubart, Anaïs; Rocha-Pereira, Joana; Galloux, Marie; Le Goffic, Ronan; Stellacci, Francesco; Cagno, Valeria
Use of NAMs in a weight of evidence approach to evaluate the safety via the inhalation route of acetylated vetiver oil, in spray products
Regulatory Toxicology and Pharmacology (Nov. 2025)
Boisleve, Fanny; Vandecasteele, Hind Assaf; Baily, James; Czuchrowski, Kamil; Diop, Malik; Gadras, Catherine; Herbst, David; Hickey, Christina; Irizar, Amaia; Müller, Boris P.; Sadekar, Nikaeta; Sterchele, Paul; Vey, Matthias; Hewitt, Nicola J.
Structure-Guided Optimization and Functional Characterization of Small Molecule Antagonists Targeting CD28 Costimulation
nan (Oct. 2025)
Upadhyay, Saurabh; Nada, Hossam; Cho, Sungwoo; Gabr, Moustafa T.
The effects of e-cigarette aerosol components on the morphology and function of the conducting portion of the respiratory system: a narrative literature review
Pomeranian Journal of Life Sciences (Jun. 2024)
Szumilas, Paweł; Szumilas, Kamila; Wilk, Aleksandra; Zawiślak, Alicja; Karakiewicz, Beata
Divergent trajectory of replication and intrinsic pathogenicity of SARS-CoV-2 Omicron post-BA.2/5 subvariants in the upper and lower respiratory tract
eBioMedicine (Jan. 2024)
Hu, Bingjie; Chan, Jasper Fuk-Woo; Liu, Yuanchen; Liu, Huan; Chen, Yan-Xia; Shuai, Huiping; Hu, Ye-Fan; Hartnoll, Madeline; Chen, Li; Xia, Yao; Hu, Jing-Chu; Yuen, Terrence Tsz-Tai; Yoon, Chaemin; Hou, Yuxin; Huang, Xiner; Chai, Yue; Zhu, Tianrenzheng; Shi, Jialu; Wang, Yang; He, Yixin; Cai, Jian-Piao; Zhou, Jie; Yuan, Shuofeng; Zhang, Jinxia; Huang, Jian-Dong; Yuen, Kwok-Yung; To, Kelvin Kai-Wang; Zhang, Bao-Zhong; Chu, Hin
The triple combination of Remdesivir (GS-441524), Molnupiravir and Ribavirin is highly efficient in inhibiting coronavirus replication in human nasal airway epithelial cell cultures and in a hamster infection model
Antiviral Research (Nov. 2024)
Do, Thuc Nguyen Dan; Abdelnabi, Rana; Boda, Bernadett; Constant, Samuel; Neyts, Johan; Jochmans, Dirk
Inefficient antiviral response in reconstituted small-airway epithelium from chronic obstructive pulmonary disease patients following human parainfluenza virus type 3 infection
Virology Journal (Apr. 2024)
Bondeelle, Louise; Salmona, Maud; Houdouin, Véronique; Diaz, Elise; Dutrieux, Jacques; Mercier-Delarue, Séverine; Constant, Samuel; Huang, Song; Bergeron, Anne; LeGoff, Jérôme